・Ultrafast Sensitivity-Controlled and Specific Detection of Extracellular Vesicles Using Optical Force with antibody-modified microparticles in a Microflow System Kana Fujiwara, Yumiko Takagi, Mamoru Tamura, Mika Omura, Kenta Morimoto, Ikuhiko Nakase*, Shiho Tokonami* and Takuya Iida* Nanoscale Horizons 8, 1034-1042 (2023)
・Gene Delivery into T cells using Ternary Complexes of DNA, Lipofectamine, and Carboxy-terminal Phenylalanine-modified Dendrimers Chie Kojima*, Mei Sawada, Ikuhiko Nakase, Akikazu Matsumoto Macromolecular Bioscience e2300139 (2023)
・Inkjet-based intracellular delivery system that effectively utilizes cell-penetrating peptides for cytosolic introduction of biomacromolecules through the cell membrane Mika Omura, Kenta Morimoto, Yurina Araki, Hisaaki Hirose, Yoshimasa Kawaguchi, Yukiya Kitayama, Yuto Goto, Atsushi Harada, Ikuo Fujii, Tomoka Takatani-Nakase, Shiroh Futaki, Ikuhiko Nakase* ACS Applied Materials & Interfaces 15, 47855-47865 (2023)
・Extracellular microvesicles modified with arginine-rich peptides for active macropinocytosis induction and delivery of therapeutic molecules Kenta Morimoto, Jojiro Ishitobi, Kosuke Noguchi, Ryoichi Kira, Yukiya Kitayama, Yuto Goto, Daisuke Fujiwara, Masataka Michigami, Atsushi Harada, Tomoka Takatani-Nakase, Ikuo Fujii, Shiroh Futaki, Masamitsu Kanada*, and Ikuhiko Nakase* ACS Applied Materials & Interfaces (accepted)
・Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer Tomoka Takatani-Nakase*, Chinami Ikushima, Manami Sakitani, and Ikuhiko Nakase* Life Sciences (accepted)
・Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths Fadlina Aulia, Hiroaki Matsuba, Shoya Adachi, Takumi Yamada, Ikuhiko Nakase, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura* Journal of Materials Chemistry B (accepted)
2022年
・Dodecaborate-encapsulated extracellular vesicles with modification of cell-penetrating peptides for enhancing macropinocytotic cellular uptake and biological activity in boron neutron capture therapy Shiori Hirase, Ayako Aoki, Yoshihide Hattori, Kenta Morimoto, Kosuke Noguchi, Ikuo Fujii, Tomoka Takatani-Nakase, Shiroh Futaki, Mitsunori Kirihata, Ikuhiko Nakase Molecular Pharmaceutics 19, 1135-1145 (2022)
・Light-induced condensation of biofunctional molecules around targeted living cells to acceleratecytosolic delivery Ikuhiko Nakase*, Moe Miyai, Kosuke Noguchi, Mamoru Tamura, Yasuyuki Yamamoto, Yushi Nishimura, Mika Omura, Kota Hayashi, Shiroh Futaki, Shiho Tokonami*, Takuya Iida* Nano Letters 22, 9805-9814 (2022)
・Stearylated macropinocytosis-inducing peptides facilitating the cellular uptake of small extracellular vesicles Yuna Nakagawa, Jan Vincent Arafiles, Yoshimasa Kawaguchi, Ikuhiko Nakase, Hisaaki Hirose, Shiroh Futaki* Bioconjugate Chemistry 33, 869-880 (2022)
・Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice Teppei Matsuda, Kazuki Misato, Shigeyuki Tamiya, Yasuhiro Akeda, Ikuhiko Nakase, Etsushi Kuroda, Shokichi Takahama, Motohiro Nonaka, Takuya Yamamoto, Michiko N. Fukuda, Yasuo Yoshioka* iScience 25, 105324 (2022)
・Controlled release of canine MSC-derived extracellular vesicles by cationized gelatin hydrogels Karin Yoshizaki, Hidetaka Nishida*, Yasuhiko Tabata*, Jun-ichiro Jo, Ikuhiko Nakase and Hideo Akiyoshi Regenerative Therapy 22, 1-6 (2022)
・A universal method to analyze cellular internalization mechanisms via endocytosis without non-specific cross-effects Mai Itagaki, Yoshinori Nasu, Chiaki Sugiyama, Ikuhiko Nakase, Noriyasu Kamei* The FASEB Journal 37, e22764 (2023)
・New class of drug modalities: directed evolution of a de novo designed helix-loop-helix peptide to bind VEGF for tumor growth inhibition Masataka Michigami, Tharanga M.R. Ramanayake Mudiyanselage, Miho Suzuki, Hirotsugu Ishizako, Kunpei Notsu, Kikuya Sugiura, Ikuo Fujii* ACS Chemical Biology, 17, 647-653 (2022)
・Human and mouse cross-reactive ” albumin-binding helix-loop-helix peptide tag for prolonged bioactivity of therapeutic proteins Yuto Nakatani, Zhengmao Ye, Yuki Ishizue, Taishi Higashi, Teruko Imai, Ikuo Fujii, Masataka Michigami* Molecular Pharmaceutics 19, 2279-2286 (2022)
・T-cell association of carboxy-terminal dendrimers with different bound numbers of phenylalanine and their application to drug delivery Hiroya Shiba, Tomoka Hirose, Yunshen Fu, Masataka Michigami, Ikuo Fujii, Ikuhiko Nakase, Akikazu Matusmoto, Chie Kojima* Pharmaceutics 15, 888 (2023)
・Generation of inhibitory peptides for IKKε from a kinase-focused phage library of helix-loop-helix peptides Kousuke Mihara, Natsumi Nakajima, Ikuo Fujii, Daisuke Fujiwara* Peptide Science, 114, e24254 (2022)
2021年
・Environmental pH stress influences cellular secretion and uptake of extracellular vesicles Ikuhiko Nakase*, Natsumi Ueno, Mie Matsuzawa, Kosuke Noguchi, Mami Hirano, Mika Omura, Tomoya Takenaka, Ayaka Sugiyama, Nahoko Bailey Kobayashi, Takuya Hashimoto, Tomoka Takatani-Nakase, Eiji Yuba, Ikuo Fujii, Shiroh Futaki, and Tetsuhiko Yoshida FEBS Open Bio 11, 753-767 (2021)
・A “ligand-targeting” peptide-drug conjugate: Targeted intracellular drug delivery by VEGF-binding helix-loop-helix peptides via receptor-mediated endocytosis Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii* PLoS One, 16, e0247045 (2021)
・Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages Masahide Inoue, Koji Sakamoto, Atsushi Suzuki, Shinya Nakai, Akira Ando, Yukihiko Shiraki, Yoshio Nakahara, Mika Omura, Atsushi Enomoto, Ikuhiko Nakase, Makoto Sawada, Naozumi Hashimoto Particle and Fibre Toxicology 18, 21 (2021)
・Carboxy-terminal dendrimers with phenylalanine for pH-sensitive delivery system into immune cells including T cells Hiroya Shiba, Misaki Nishio, Mei Sawada, Mamiko Tamaki, Masataka Michigami, Shinya Nakai, Ikuhiko Nakase, Ikuo Fujii, Akikazu Matsumoto, Chie Kojima* Journal of Materials Chemistry B 10, 2463-2470 (2021)
・Hypoxia enhances motility and EMT through the Na+/H+ exchanger NHE-1 in MDA-MB-231 breast cancer cells Tomoka Takatani-Nakase*, Chihiro Matsui, Maiko Hosotani, Mika Omura, Koichi Takahashi, and Ikuhiko Nakase* Experimental Cell Research 412, 113006 (2022)
・Key process and factors controlling the direct translocation of cell-penetrating peptide through bio-membrane Kazutami Sakamoto*, Taku Morishita, Kenichi Aburai, Kenichi Sakai, Masahiko Abe, Ikuhiko Nakase, Shiroh Futaki, Hideki Sakai International Journal of Molecular Sciences, 21, 5466 (2020)
・Antibody-based receptor targeting using an Fc-binding peptide-dodecaborate conjugate and macropinocytosis induction for boron neutron capture therapy (BNCT) Ikuhiko Nakase*, Ayako Aoki, Yuriko Sakai, Shiori Hirase, Miki Ishimura, Tomoka Takatani-Nakase, Yoshihide Hattori*, Mitsunori Kirihata* ACS Omega,5, 22731 (2020)
・Direct entry of cell-penetrating peptide can be controlled by maneuvering the membrane curvature Kazutami Sakamoto,* Taku Morishita, Kenichi Aburai, Daisuke Ito, Tomohiro Imura, Kenichi Sakai, Masahiko Abe, Ikuhiko Nakase, Shiroh Futaki, and Hideki Sakai Scientific Reports (accepted)
2019年
・Rapid optical tissue clearing using poly(acrylamide-co-styrenesulfonate) hydrogels for three-dimensional imaging Yuuta Ohno, Ikuhiko Nakase, Akikazu Matsumoto*, and Chie Kojima* Journal of Biomedical Materials Research: Part B 107, 2297-2304 (2019)
・An oligoarginine-bearing tandem repeat penetration-accelerating sequence delivers protein to the cytosol via caveolae-mediated endocytosis Akiko Okuda*, Shinya Tahara, Hisaaki Hirose, Toshihide Takeuchi, Ikuhiko Nakase, Atsushi Ono, Masanori Takehashi, Seigo Tanaka, Shiroh Futaki Biomacromolecules 20, 1849-1859 (2019)
・The peptides around the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating peptides via binding to heparan sulfate and neuropilins Yasuyuki Yamamoto, Shigeyuki Tamiya, Meito Shibuya, Ikuhiko Nakase, and Yasuo Yoshioka* Biochemical and Biophysical Research Communications 512, 453-459 (2019)
・Optimization of the method for analyzing endocytosis of fluorescently tagged molecules: Impact of incubation in the cell culture medium and cell surface wash with glycine-hydrochloric acid buffer Noriyasu Kamei*, Satoshi Yamamoto, Hiro Hashimoto, Megumi Nishii, Moe Miyaura, Kiho Tomada, Ikuhiko Nakase, Mariko Takeda-Morishita Journal of Controlled Release 310, 127-140 (2019)
・Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT) Ikuhiko Nakase*, Miku Katayama, Yoshihide Hattori*, Miki Ishimura, Shunsuke Inaura, Daisuke Fujiwara, Tomoka Takatani-Nakase, Ikuo Fujii, Shiroh Futaki, and Mitsunori Kirihata* Chemical Communications 55, 13955-13958 (2019)
・Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells Tomoya Takenaka, Shinya Nakai, Miku Katayama, Mami Hirano, Natsumi Ueno, Kosuke Noguchi, Tomoka Takatani-Nakase, Ikuo Fujii, Susumu S. Kobayashi* and Ikuhiko Nakase* International Journal of Pharmaceutics 572, 118762 (2019)
・Conversion of cationic amphiphilic lytic peptides to cell-penetration peptides Hao-Hsin Yu, Kentarou Sakamoto, Misao Akishiba, Naoki Tamemoto, Hisaaki Hirose, Ikuhiko Nakase, Miki Imanishi, Fatemeh Madani, Astrid Gräslund, and Shiroh Futaki* Biopolymers-Peptide Science 112, e24114 (2020)
・Effects of lyophilization of arginine-rich cell-penetrating peptide-modified extracellular vesicles on intracellular delivery Kosuke Noguchi, Mami Hirano, Takuya Hashimoto, Eiji Yuba, Tomoka Takatani-Nakase and Ikuhiko Nakase* Anticancer Research 39, 6701-6709 (2019)
2018年
・Modular Redesign of a Cationic Lytic Peptide to Promote the Endosomal Escape of Biomacromolecules Yusuke Azuma, Haruka Imai, Yoshimasa Kawaguchi, Ikuhiko Nakase, Hiroshi Kimura, and Shiroh Futaki* Angewandte Chemie International Edition 57, 12771-12774 (2018).
・Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells Masaya Hagiwara*, Ikuhiko Nakase Biochemical and Biophysical Research Communications 507, 297-303 (2018).
2017年
・Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery Ikuhiko Nakase*, Kosuke Noguchi, Ayako Aoki, Tomoka Takatani-Nakase, Ikuo Fujii, Shiroh Futaki Scientific Reports 7, 1991 (2017)
・Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death Tomoka Takatani-Nakase,* Miku Katayama, Chihiro Matsui, Kenjiro Hanaoka, André J. van der Vlies, Koichi Takahashi, Ikuhiko Nakase,* and Urara Hasegawa* Molecular BioSystems 13, 1705-1708 (2017)
・Gefitinib enhances mitochondrial biological functions in NSCLCs with EGFR mutations at a high cell density Tomoya Takenaka, Miku Katayama, Ayaka Sugiyama, Masaya Hagiwara, Ikuo Fujii, Tomoka Takatani-Nakase, Susumu S. Kobayashi*, Ikuhiko Nakase* Anticancer Research 37, 4779-4788 (2017)
・Zinc and its transporter ZIP6 are key mediators of breast cancer cell survival under high glucose conditions Chihiro Matsui, Tomoka Takatani-Nakase*, Yuki Hatano, Satomi Kawahara, Ikuhiko Nakase*, and Koichi Takahashi* FEBS Letters 591, 3348-3359 (2017)
・Potential Roles of GLUT12 for Glucose Sensing and Cellular Migration in MCF-7 Human Breast Cancer Cells Under High Glucose Conditions Chihiro Matsui, Tomoka Takatani-Nakase*, Sachie Maeda, Ikuhiko Nakase* and Koichi Takahashi* Anticancer Research 37, 6715-6722 (2017)
・Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Intracellular Protein-Protein Interaction Inhibitors by Epitope and Arginine Grafting Daisuke Fujiwara, Hidekazu Kitada, Masahiro Oguri, Toshio Nishihara, Masataka Michigami, Kazunori Shiraishi, Eiji Yuba, Ikuhiko Nakase, Haeri Im, Sunhee Cho, Jong Young Joung, Seiji Kodama, Kenji Kono, Sihyun Ham, and Ikuo Fujii Angewandte Chemie International Edition 55, 10612-10615 (2016)
・Syndecan-4 is a receptor for clathrin-mediated endocytosis of arginine-rich cell-penetrating peptides Yoshimasa Kawaguchi, Toshihide Takeuchi, Keiko Kuwata, Junya Chiba, Yasumaru Hatanaka, Ikuhiko Nakase, Shiroh Futaki Bioconjugate Chemistry 27, 1119-1130 (2016)
・Uncatalyzed Click Reaction between Phenyl Azides and Acrolein: 4-Formyl-1,2,3-Triazolines as “Clicked” Markers for Visualizations of Extracellular Acrolein Released from Oxidatively Stressed Cells Ambara Pradipta, Misako Taichi, Ikuhiko Nakase*, Elena Saigitbatalova, Almira Kurbangalieva, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka* ACS Sensors, 1, 623–632 (2016)
・Vectorization of biomacromolecules into cells using extracellular vesicles with enhanced internalization induced by macropinocytosis Ikuhiko Nakase*, Kosuke Noguchi, Ikuo Fujii, Shiroh Futaki Scientific Reports 6, 34937 (2016)
・Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes Ikuhiko Nakase*, Natsumi Ueno, Miku Katayama, Kosuke Noguchi, Tomoka Takatani-Nakase, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida, Ikuo Fujii, and Shiroh Futaki Chemical Communications 53, 317-320 (2017)
2015年
・Effect of amino acid substitution in the hydrophobic face of amphiphilic peptides on membrane curvature and perturbation: N-terminal helix derived from adenovirus internal protein VI as a model Tomo Murayama, Silvia Pujals, Hisaaki Hirose, Ikuhiko Nakase, and Shiroh Futaki Biopolymers (Peptide Science) 106, 430-439 (2016)
・Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells Yoshihiro Kuroda, Nahoko Kato-Kogoe, Emi Tasaki, Mayumi Yuasa-Sunagawa, Koji Yamanegi, Keiji Nakasyo, Ikuhiko Nakase, Shiroh Futaki, Yumi Tohyama, Munetaka Hirose European Journal of Pharmacology 765, 24-33 (2015)
・Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes Ikuhiko Nakase, Shiroh Futaki Scientific Reports 5, 10112 (2015)
・Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes Ikuhiko Nakase, Nahoko Bailey Kobayashi, Tomoka Takatani-Nakase, Tetsuhiko Yoshida Scientific Reports 5, 10300 (2015)
・Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα Ikuhiko Nakase, Katsuhiro Osaki, Gen Tanaka, Atsushi Utani, Shiroh Futaki Biochemical and Biophysical Research Communications 446, 857-862 (2014)
・Controlling leucine-zipper partner recognition in cells through modification of a–g interactions Yusuke Azuma, Tim Kukenshoner, Guangyong Ma, Jun-ichiro Yasunaga, Miki Imanishi, Gen Tanaka, Ikuhiko Nakase, Takahiro Maruno, Yuji Kobayashi, Katja M. Arndt, Masao Matsuoka and Shiroh Futaki Chemical Communications 50, 6364-6367 (2014).
2013年
・Oligopeptides derived from autiphosphorylation sites of EGF receptor suppress EGF- stimulated responses in human lung carcinoma A549 cells Yoshihiro Kuroda, Nahoko Kato-Kogoe, Emi Tasaki, Eri Murata, Koyo Ueda, Mineo Abe, Kazuhide Miyamoto, Ikuhiko Nakase, Shiroh Futaki, Yumi Tohyama, Munetaka Hirose European Journal of Pharmacology 698, 87-94 (2013)
・Identification of cellular proteins interacting with octaarginine (R8) cell-penetrating peptide by photo-crosslinking Yoshimasa Kawaguchi, Gen Tanaka, Ikuhiko Nakase, Miki Imanishi, Junya Chiba, Yasumaru Hatanaka, Shiroh Futaki Bioorganic & Medicinal Chemistry Letters 23, 3738-3740 (2013)
・Effects of pyrenebutyrate on the translocation of arginine-rich cell-penetrating peptides through artificial membranes: Recruting peptides to the membranes, dissipating liquid- ordered phases, and including curvature Sayaka Katayama, Ikuhiko Nakase, Yoshiaki Yano, Tomo Murayama, Yasushi Nakata, Yoshiaki Okada, Katsumi Matsuzaki, Shiroh Futaki Biochemica et Biophysica Acta-Biomembranes 1828, 2134-2142 (2013)
・Development of a novel nanoparticle by dual modification with the pluripotential cell- penetrating peptide PepFect6 for cellular uptake, endosomal escape and decondensation of an siRNA core complex Asako Mitsueda, Yuri Shimatani, Masahiro Ito, Takashi Ohgita, Asako Yamada, Susumu Hama, Astrid Gräslund, Staffan Lindberg, Ulo Langel, Hideyoshi Harashima, Ikuhiko Nakase, Shiroh Futaki, Kentaro Kogure Biopolymers (Peptide Science) 100, 698-704 (2013)
・Curvature engineering: positive membrane curvature induced by epsin N-terminal peptide boosts internalization of octaarginine Silvia Pujals, Hiroki Miyamae, Sergii Afonin, Tomo Murayama, Hisaaki Hirose, Ikuhiko Nakase, Kentaro Taniuchi, Masato Umeda, Kazutami Sakamoto, Anne S. Ulrich, Shiroh Futaki ACS Chemical Biology 8, 1894-1899 (2013)
2012年
・Transient focal membrane deformation induced by arginine-rich peptides leads to their direct penetration into cells Hisaaki Hirose, Toshihide Takeuchi, Hiroko Osakada, Sílvia Pujals, Ikuhiko Nakase, Shouhei Kobayashi, Tokuko Haraguchi, Shiroh Futaki Molecular Therapy 20, 984-993 (2012)
・Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo Ikuhiko Nakase, Yusuke Konishi, Masashi Ueda, Hideo Saji, Shiroh Futaki Journal of Controlled Release 159, 181-188 (2012)
・The effect of the attachment of a penetration accelerating sequence and the influence of hydrophobicity on octaarginine-mediated intracellular delivery Kentaro Takayama, Hisaaki Hirose, Gen Tanaka, Sílvia Pujals, Sayaka Katayama, Ikuhiko Nakase, Shiroh Futaki Molecular Pharmaceutics 9, 1222-1230 (2012)
・Signal transduction using an artificial receptor system that undergoes dimerization upon addition of a bivalent leucine-zipper ligand Ikuhiko Nakase, Shinya Okumura, Gen Tanaka, Katsuhiro Osaki, Miki Imanishi, Shiroh Futaki Angewandte Chemie International Edition 51, 7464-7467 (2012)
・Bio-inspired mechanism for the translocation of peptide through the cell-membrane Kazutami Sakamoto, Kenichi Aburai, Taku Morishita, Kenichi Sakai, Hideki Sakai, Masahiko Abe, Ikuhiko Nakase, and Shiroh Futaki Chemistry Letters 41, 1078-1080 (2012)
・CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV Gen Tanaka, Ikuhiko Nakase, Yasunori Fukuda, Ryo Masuda, Shinya Oishi, Kazuya Shimura, Yoshimasa Kawaguchi, Tomoka Takatani-Nakase, Ülo Langel, Astrid Gräslund, Katsuya Okawa, Masao Matsuoka, Nobutaka Fujii, Yasumaru Hatanaka and Shiroh Futaki Chemistry & Biology 19, 1437-1446 (2012)
・Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine Ikuhiko Nakase, Shinya Okumura, Sayaka Katayama, Hisaaki Hirose, Sílvia Pujals, Hirofumi Yamaguchi, Satoko Arakawa, Shigeomi Shimizu, Shiroh Futaki Chemical Communications 48, 11097-11099 (2012)
2011年
・Acylation of octaarginine: implication to the use of intracellular delivery vectors Sayaka Katayama, Hisaaki Hirose, Kentaro Takayama, Ikuhiko Nakase, Shiroh Futaki Journal of Controlled Release 149, 29-35 (2011)
2010年
・Expressed protein ligation for the preparation of fusion proteins with cell penetrating peptides for endotoxin removal and intracellular delivery Hao-Hsin Yu, Ikuhiko Nakase, Sílvia Pujals, Hisaaki Hirose, Gen Tanaka, Sayaka Katayama, Miki Imanishi, and Shiroh Futaki Biochimica et Biophysica Acta-Biomembranes 1798, 2249-2257 (2010)
・Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4 Kazuki Shimane, Eiichi N. Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G. Sarafianos, Masao Matsuoka International Journal of Biochemistry & Cell Biology 42, 1482-1488 (2010)
・Enhanced target-specific accumulation of radiolabeled antibodies by conjugating arginine-rich peptides as anchoring molecules Rei Miyamoto, Hiromichi Akizawa, Takeshi Nishikawa, Tomoya Uehara, Yusuke Azuma, Ikuhiko Nakase, Shiroh Futaki, Hirofumi Hanaoka, Yasuhiko Iida, Keigo Endo, Yasushi Arano Bioconjugate Chemistry 21, 2031-2037 (2010)
2009年以前
・Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosis Ikuhiko Nakase, Byron Gallis, Tomoka Takatani-Nakase, Steve Oh, Eric Lacoste, Narendra P. Singh, David R. Goodlett, Seigo Tanaka, Shiroh Futaki, and Tomikazu Sasaki Cancer Letters 274, 290-298 (2009)
・Novel system to achieve one-pot modification of cargo molecules with oligoarginine vectors for intracellular delivery Kentaro Takayama, Akiko Tadokoro, Silvia Pujals, Ikuhiko Nakase, Ernest Giralt, Shiroh Futaki Bioconjugate Chemistry 20, 249-257 (2009)
・High-resolution multi-dimensional NMR spectroscopy of proteins in living human cells Kohsuke Inomata, Ayako Ohno, Hidehito Tochio, Shin Isogai, Takeshi Tenno, Ikuhiko Nakase, Toshihide Takeuchi, Shiroh Futaki, Yutaka Ito, Hidekazu Hiroaki, and Masahiro Shirakawa Nature 458, 106-109 (2009)
・Cytosolic targeting of macromolecules using a pH-dependent fusogenic peptide in combination with cationic liposomes Sachiko Kobayashi, Ikuhiko Nakase, Noriko Kawabata, Hao-Hsin Yu, Silvia Pujals, Miki Imanishi, Ernest Giralt, Shiroh Futaki Bioconjugate Chemistry 20, 953-959 (2009)
・Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD Catherine L. Watkins, Paul Brennan, Christopher Fegan, Kentaro Takayama, Ikuhiko Nakase, Shiroh Futaki, Arwyn T. Jones Journal of Controlled Release 140, 237-244 (2009)
・Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas) Kentaro Takayama, Ikuhiko Nakase, Hiroyuki Michiue, Toshihide Takeuchi, Kazuhito Tomizawa, Hideki Matsui, Shiroh Futaki Journal of Controlled Release 138, 128-133 (2009)
・Mesostructured silica based delivery system for a drug with a peptide as a cell-penetrate vector Chuanbo Gao, Isabel Izquierdo-Barba, Ikuhiko Nakase, Shiroh Futaki, Juanfang Ruan, Kazutami Sakamoto, Yasuhiro Sakamoto, Kazuyuki Kuroda, Osamu Terasaki, Shunai Che Microporous and Mesoporous Materials 122, 201-207 (2009)
・Artemisinin-transferrin conjugate retards growth of breast tumors in the rat Henry Lai, Ikuhiko Nakase, Eric Lacoste, Narendra P. Singh and Tomikazu Sasaki Anticancer Research 29, 3807-3810 (2009)
・Cell surface accumulation of flock house virus-derived peptide leads to efficient internalization via macropinocytosis Ikuhiko Nakase, Hisaaki Hirose, Gen Tanaka, Akiko Tadokoro, Sachiko Kobayashi, Toshihide Takeuchi, and Shiroh Futaki Molecular Therapy 17, 1868-1876 (2009)
・Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans Michie Kosuge, Toshihide Takeuchi, Ikuhiko Nakase, Arwyn T. Jones, Shiroh Futaki Bioconjugate Chemistry 19, 656-664 (2008)
・Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis Ikuhiko Nakase, Akiko Tadokoro, Noriko Kawabata, Toshihide Takeuchi, Hironori Katoh, Kiyo Hiramoto, Manabu Negishi, Motoyoshi Nomizu, Yukio Sugiura, and Shiroh Futaki Biochemistry 46, 492-501 (2007)
・Temperature, concentration and cholesterol dependent translocation of L- and D-octaarginine across the plasma and nuclear membrane of CD34 + leukaemia cells Marjan M. Fretz, Neal A. Penning, Saly Al-Taei, Shiroh Futaki, Toshihide Takeuchi, Ikuhiko Nakase, Gert Storm, and Arwyn T. Jones Biochemical Journal 403, 335-342 (2007)
・Acid wash in determining cellular uptake of Fab/cell-permeating peptide conjugates Shouju Kameyama, Mayo Horie, Takeo Kikuchi, Takao Omura, Akiko Tadokoro, Toshihide Takeuchi, Ikuhiko Nakase, Yukio Sugiura, and Shiroh Futaki Biopolymers 88, 98-107 (2007)
・Distribution of immunoglobulin Fab fragment conjugated with HIV-1 REV peptide following intravenous administration in rats Shouju Kameyama, Ritsuko Okada, Takeo Kikuchi, Takao Omura, Ikuhiko Nakase, Toshihide Takeuchi, Yukio Sugiura, and Shiroh Futaki Molecular Pharmaceutics 3, 174-180 (2006)
・Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors Saly Al-Taei, Neal A. Penning, Jeremy C. Simpson, Shiroh Futaki, Toshihide Takeuchi, Ikuhiko Nakase, and Arwyn T. Jones Bioconjugate Chemistry 17, 90-100 (2006)
・Effects of cell-permeating peptide binding on the distribution of 125I-labeled Fab fragment in rats Shouju Kameyama, Mayo Horie, Takeo Kikuchi, Takao Omura, Toshihide Takeuchi, Ikuhiko Nakase, Yukio Sugiura, and Shiroh Futaki Bioconjugate Chemistry 17, 597-602 (2006)
・Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine Marjan Fretz, Jing Jin, Robin Conibere, Neal A. Penning, Saly Al-Taei, Gert Storm, Shiroh Futaki, Toshihide Takeuchi, Ikuhiko Nakase and Arwyn T. Jones Journal of Controlled Release 116, 247-254 (2006)
・RNase S complex bearing arginine-rich peptide and anti-HIV activity Shiroh Futaki, Ikuhiko Nakase, Tomoki Suzuki, Daisuke Nameki, Ei-ichi Kodama, Masao Matsuoka, and Yukio Sugiura Journal of Molecular Recognition 18, 169-174 (2005)
・Unique features of a pH-sensitive fusogenic peptide that improves the transfection efficiency of cationic liposomes Shiroh Futaki, Yumi Masui, Ikuhiko Nakase, Yukio Sugiura, Takashi Nakamura, Kentaro Kogure, and Hideyoshi Harashima Journal of Gene Medicine 7, 1450-1458 (2005)
・Gramicidin-based channel systems for the detection of protein-ligand interaction Shiroh Futaki, Youjun Zhang, Tatsuto Kiwada, Ikuhiko Nakase, Takeshi Yagami, Shigetoshi Oiki and Yukio Sugiura Bioorganic & Medicinal Chemistry 12, 1343-1350 (2004)
・Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system Tomoyuki Kakudo, Shinji Chaki, Shiroh Futaki, Ikuhiko Nakase, Kenichi Akaji, Toru Kawakami, Kazuo Maruyama, Hiroyuki Kamiya, and Hideyoshi Harashima Biochemistry 43, 5618-5628 (2004)
・Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement Ikuhiko Nakase, Miki Niwa, Toshihide Takeuchi, Kazuhiro Sonomura, Noriko Kawabata, Yukihiro Koike, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda, Jeremy C. Simpson, Arwyn T. Jones, Yukio Sugiura, and Shiroh Futaki Molecular Therapy 10, 1011-1022 (2004)
・Translocation of branched-chain arginine peptides through cell membranes: flexibility in the spatial disposition of positive charges in membrane-permeable peptides Shiroh Futaki, Ikuhiko Nakase, Tomoki Suzuki, Zhang Youjun, and Yukio Sugiura Biochemistry 41, 7925-7930 (2002)
・A ‘Cassette’ RNase: site-selective cleavage of RNA by RNase S equipped with RNA- recognition segment Shiroh Futaki, Michihiro Araki, Tatsuto Kiwada, Ikuhiko Nakase and Yukio Sugiura Bioorganic & Medicinal Chemistry Letters 11, 1165-1168 (2001)
II. Reviews (peer-reviewed)
1. Structural variety of membrane permeable peptides Shiroh Futaki, Susumu Goto, Tomoki Suzuki, Ikuhiko Nakase and Yukio Sugiura Current Protein & Peptide Science 4, 87-96 (2003)
2. Arginine-rich peptides and their internalization mechanisms Shiroh Futaki, Ikuhiko Nakase, Akiko Tadokoro, Toshihide Takeuchi, Arwyn T. Jones Biochemical Society Transactions 35, 784-787 (2007)
3. Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation Ikuhiko Nakase, Henry Lai, Narendra P. Singh, Tomikazu Sasaki International Journal of Pharmaceutics 354, 28-33 (2008)
4. Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides Ikuhiko Nakase, Toshihide Takeuchi, Gen Tanaka, Shiroh Futaki Advanced Drug Delivery Reviews 60, 598-607 (2008)
5. Endosome-disruptive peptides for improving cytosolic delivery of bioactive macromolecules Ikuhiko Nakase, Sachiko Kobayashi, Shiroh Futaki Biopolymers 94, 763-770 (2010)
6. Application of a fusiogenic peptide GALA for intracellular delivery. Ikuhiko Nakase, Kentaro Kogure, Hideyoshi Harashima, Shiroh Futaki. Methods in Molecular Biology 683, 525-533 (2011)
7. Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides Ikuhiko Nakase, Hidetaka Akita, Kentaro Kogure, Astrid Gräslund, Ulo Langel, Hideyoshi Harashima, Shiroh Futaki Accounts of Chemical Research 45, 1132-1139 (2012)
8. Arginine-rich peptides: methods of translocation through biological membranes Shiroh Futaki, Hisaaki Hirose, Ikuhiko Nakase Current Pharmaceutical Design 19, 2863-2868 (2013)
9. Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells Ikuhiko Nakase, Gen Tanaka, Shiroh Futaki Molecular Biosystems 9, 855-861 (2013)
10. Cellular uptake of arginine-rich cell-penetrating peptides and the contribution of membrane-associated proteoglycans Ikuhiko Nakase, Yoshimasa Kawaguchi, Motoyoshi Nomizu, and Shiroh Futaki Trends in Glycoscience and Glycotechnology 27, 81-88 (2015)
11. Chemical Biology for Pharmaceutical Science-Integrative Approaches for Elucidation of Biological Phenomena- Ikuhiko Nakase, Wataru Nomura Yakugaku Zasshi 135, 373-374 (2015)
12. Creation of Artificial Receptors Activated by Coiled-coil Peptides and Cellular Regulation Ikuhiko Nakase Yakugaku Zasshi 135, 375-381 (2015)
13. Cell penetrating peptides for chemical biological studies Ikuhiko Nakase, Toshihide Takeuchi, and Shiroh Futaki Methods in Molecular Biology 1324, 387-396 (2015).
14. Cell-surface interactions on arginine-rich cell-penetrating peptides allow for multiplex modes of internalization Shiroh Futaki,* Ikuhiko Nakase Accounts in Chemical Research 50, 2449-2456 (2017)
15. Photoaffinity Labeling Methods to Explore Internalization Mechanisms of Arginine-Rich Cell-Penetrating Peptides Gen Tanaka, Yoshimasa Kawaguchi, Keiko Kuwata, Toshihide Takeuchi, Ikuhiko Nakase, Shiroh Futaki* Photoaffinity Labeling for Structural Probing within Protein (Editors: Yasumaru Hatanaka, Makoto Hashimoto) Springer Japan Chapter11: Pages: 225-240 (2017)
16. Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions) Maria Serena Fabbrini, Miku Katayama, Ikuhiko Nakase and Riccardo Vago* Toxins 9, E314 (2017)
17. Biofunctional peptide-modified extracellular vesicles enable effective intracellular delivery via the induction of macropinocytosis Ikuhiko Nakase* Processes 9, 224 (2021)
18. Exosomes: breast cancer-derived extracellular vesicles; recent key findings and technologies in disease progression, diagnostics, and cancer targeting Ikuhiko Nakase* and Tomoka Takatani-Nakase* Drug Metabolism and Pharmacokinetics (accepted)
19. ZIP6-centered zinc regulatory and malignant characteristics of breast cancer cells Tomoka Takatani-Nakase*, Chihiro Matsuia, Manami Sakitania, and Ikuhiko Nakase Metallomics Research (accepted)
20. Arginine-Rich Cell-Penetrating Peptides: Recent Advances of Design and Applications for Intracellular Delivery Ikuhiko Nakase Oba, Demizu (Eds.): Cell-Penetrating Peptides. Design, Development and Applications WILEY, pp29-44 (2023)
21. Cellular Uptake Mechanisms of Arginine-Rich Cell-Penetrating Peptides」 Ikuhiko Nakase Oba, Demizu (Eds.): Cell-Penetrating Peptides. Design, Development and Applications WILEY, pp141-158 (2023)
21. 機能性ペプチド修飾型エクソソームを用いた細胞内薬物導入技術 野口公輔、中瀬生彦 「ペプチド創薬の最前線/The Frontier of Peptide Drug Discovery」 監修：木曽良明 （第16章 分担） シーエムシー出版
22. JCR掲載トピックス：受容体標的エクソソームの細胞形質膜融合と効率的な細胞質への薬物送達 （Zhen Zheng et al. Journal of Controlled Release 311-312, 43-49 (2019)） 中瀬生彦 Drug Delivery System 34, 405 (2019)
23. 機能性ペプチド修飾型エクソソームを用いた細胞内への薬物導入技術 中瀬生彦 Drug Delivery System 35, 47-56 (2020)
1. Mechanisms of cellular uptake of arginine-rich cell-penetrating peptides Ikuhiko Nakase Global COE Symposium JAPAN-CANADA Joint Health Research Program “Biomembrane and Channels” (December 10, 2010, Kyoto)
2. Mechanisms to attain efficient cellular uptake of arginine-rich cell-penetrating peptides Ikuhiko Nakase Peptide Therapeutics Conference 2012 （February 16, 2012, Puerto Calero, Lanzarote, Spain）
3. Efficient internalization of arginine-rich cell-penetrating peptides through cell membranes Ikuhiko Nakase, Shiroh Futaki Satellite mini-workshop of IACIS 2012 (May 12, 2012, Chiba)
4. Development of intracellular delivery systems based on exosomes and modification with functional peptides Ikuhiko Nakase 18th Korean Peptide Protein Society Symposium （July 8, 2014, Hanwha Resort, Haeundae, Busan, South Korea）
5. Efficient intracellular delivery using functional peptide-modified exosomes Ikuhiko Nakase Swiss-Japanese Chemical Biology Symposium 2014 （October 2, 2014, University of Bern）
7. Intracellular Delivery System Based on Biofunctional Peptide-Modified Exosomes Ikuhiko Nakase Institute for Chemical Research International Symposium 2016 (ICRIS’16) –Research Network Based on ICR MOU– (March 8, 2016, Kyoto University)
8. Biofunctional peptide-modified exosomes for intracellular delivery Ikuhiko Nakase Laboratoire des BioMolecules-LBM Seminar (UMR7203 CNRS-ENS-UPMC, Paris) （2016年9月2日、UMR7203 CNRS-ENS-UPMC, Paris, France）
9. Intracellular delivery system based on cell-penetrating peptides Ikuhiko Nakase AsiaTIDES: Oligonucleotide & Peptide Therapeutics（2017年2月23日、京都）
10. Effective usage of biofunctional peptides for intracellular delivery of therapeutic molecules Ikuhiko Nakase Research Seminar Programme: Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University（Redwood Building, Cardiff University, 2017年11月30日）
11. Overview of cell-penetrating peptides and delivery strategies for peptides Ikuhiko Nakase AsiaTIDES: Oligonucleotides & Peptide Therapeutics Pre-Conference Workshop#2 （An introduction to peptide therapeutic development: strategies for moving to the clinic, CMC and beyond）（2018年2月27日、Westin Miyako Kyoto, Kyoto）
13. Development of intracellular delivery system based on cell-penetrating peptides Ikuhiko Nakase The 6th CPC Symposium on Peptide Therapeutics （2018年10月18日、Double Tree Hotel by Hilton, Hangzhou, China）
14. Intracellular delivery system based on functional peptide-modified exosomes Ikuhiko Nakase The 6th TKU-OPU-HCMUT-DLU-TNU Joint Symposium on Chemistry and Natural Sciences (JSCNS-6) （2018年11月23日、Tamkang University, Taiwan）
15. Biofunctional Peptide-Modified Exosomes for Intracellular Delivery Ikuhiko Nakase The 24th Peptide Forum in Kyoto, 2018: International Mini-Symposium on Peptide-Membrane Interaction and Intracellular Delivery （2018年12月8日、Institute for Chemical Research, Kyoto University, Kyoto）
16. Biofunctional peptide-modified exosomes for intracellular delivery of therapeutic molecules Ikuhiko Nakase International Mini-Seminar: Application of Extracellular Vesicles “Exosomes” for Future Therapy（2019年4月23日、大阪府立大学、大阪）
＜Daisuke Fujiwara＞ 1. Generation of conformationally constrained helix-loop-helix peptides that inhibit intracellular protein–protein interactions Daisuke Fujiwara 第60回ペプチド討論会サテライトシンポジウム「International Mini-Symposium on Peptide Design and Functional Extension. A Satellite Symposium of the 60th Japanese Peptide Symposium」 （2023年 11月11日、京都大学 宇治おうばくプラザ）
8. The Second International Symposium on Biofunctional Chemistry (ISBC) 2017 （Scientific program committee） （2017年12月14-16日、京都大学宇治キャンパス きはだホール、宇治市）
9. 第28回ケミカルバイオロジー研究所セミナー Interfacing nanomaterials with biology: from CRISPR delivery to cell-based sensing Professor Vincent M. Rotello (Department of Chemistry, University of Massachusetts-Amherst) 世話人：中瀬生彦、藤原大佑 （2018年3月23日、大阪府立大学、堺市）
10. 大阪府立大学 第97回生物科学フロンティアセミナー Saporin-based chimeric fusions as therapeutic option for the treatment of solid tumors Stefania Zuppone (San Raffaele Scientific Institute, Italy) （2018年7月24日、大阪府立大学、堺市）
11. The 12th NanoSquare Workshop（Organizing committee） （2018年11月16日、大阪府立大学、堺市）
12. 10th International Peptide Symposium（International Program Committee, Local Organizing Committee） （2018年12月6日、ROHM Theatre Kyoto, Kyoto）
13. The 24th Peptide Forum in Kyoto, 2018: International Mini-Symposium on Peptide-Membrane Interaction and Intracellular Delivery （2018年12月8日、Institute for Chemical Research, Kyoto University, Kyoto） Organizers: Shiroh Futaki (Kyoto University), Jaehoon Yu (Seoul National University), Ikuhiko Nakase (Osaka Prefecture University)
14. BioMedical Forum 2019（Organizing Committee） （2019年2月4日、大阪府立大学 学術交流会館、堺市）
15. International Mini-Seminar: Application of Extracellular Vesicles “Exosomes” for Future Therapy （第31回ケミカルバイオロジー研究所セミナー、第101回生物科学フロンティアセミナー）Organizer （2019年4月23日、大阪府立大学、大阪）
37. 第118回生物科学フロンティアセミナー、第8回創薬科学研究所セミナー 「In vitro and in vivo analysis of extracellular vesicle-mediated metastasis using a bright, red-shifted bioluminescent reporter protein」 金田雅充先生（ミシガン州立大学 Assistant Professor） 世話人：中瀬生彦 （2021年12月17日、オンライン開催）
39. 第60回 日本生物物理学会年会 シンポジウム Biophysical responses and biochemical/chemical controlling of membranes for cellular regulation and future therapy（生体膜の生物物理呼応と細胞機能制御への化学的利用） Symposium organizers: Ikuhiko Nakase (Osaka Metropolitan University), Hisaaki Hirose (Kyoto University) Speakers: Prof. Dr. Christian Widmann (University of Lausanne) Prof. Dr. Junichi Ikenouchi (Kyushu University) Ms. Yuge Hou (selected from general presentations) (The University of Tokyo) Prof. Dr. Ikuhiko Nakase (Osaka Metropolitan University) Prof. Dr. Shiro Suetsugu (Nara Institute of Science and Technology) Prof. Dr. Aurélien Roux (University of Geneva) （2022年9月28日、函館アリーナ・函館市民会館）
44. 第45回日本分子細胞生物学会 シンポジウム [3PW-09] New artificial approaches for controlling functions of biological membranes and detection of biophysical communications Organizer: Ikuhiko Nakase (Graduate School of Science, Osaka Metropolitan University) Yoshiaki Yano (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) Invited speaker: Professor Dr. Mina Okochi (Tokyo Institute of Technology) Professor Dr. Chiho Watanabe (Hiroshima University) Mr. Kazutoshi Masuda (The University of Tokyo) Professor Dr. Shinsuke Sando (The University of Tokyo) Professor Dr. Sandrine Sagan (Sorbonne Université) Professor Dr. Shinya Tsukiji (Nagoya Institute of Technology) Professor Dr. Shiroh Futaki (Kyoto University) （2022年12月2日、幕張メッセ）
45. BioMedical Forum 2023 世話人：乾隆、長崎健、中瀬生彦、藤原大佑、藤井郁雄 （2023年1月31日、大阪公立大学 中百舌鳥キャンパス）
46. 第125回生物科学フロンティアセミナー、第45回ケミカルバイオロジー研究所セミナー 「Tailoring the activity spectra of cell-penetrating peptides」 Professor Dr. Ines Neundorf (Institute of Biochemistry, Department of Chemistry, University of Cologne, Germany) 世話人：中瀬生彦 （2023年5月15日、大阪公立大学 中百舌鳥キャンパス）
57. 第50回ケミカルバイオロジー研究所セミナー、第134回生物科学フロンティアセミナー 世話人：藤井郁雄、中瀬生彦 「G-protein-couples peptide receptors: state of the art and innovative therapeutic concepts」 Professor Dr. Annette G. Beck-Sickinger (Institute of Biochemistry, Faculty of Life Sciences, Leipzig University) （2023年11月7日、大阪公立大学 中百舌鳥キャンパス）
58. 第60回ペプチド討論会（Chair: Professor Dr. Hidehito Mukai, Professor Dr. Youhei Sohma） Organizing committee: Ikuo Fujii, Ikuhiko Nakase （2023年11月8-10日、びわこホール、ピアザ淡海）
59. 第51回ケミカルバイオロジー研究所セミナー、第135回生物科学フロンティアセミナー 世話人：藤井郁雄、中瀬生彦 「Cyclohexylalanine-containing alpha-helical amphipathic peptide with eukaryotic cell penetrating ability targets cardiolipin and rescues mitochondrial dysfunction」 Professor Dr. Jaehoon Yu (Department of Chemistry & Education, Seoul National University) （2023年11月13日、大阪公立大学 中百舌鳥キャンパス）
60. 第52回ケミカルバイオロジー研究所セミナー、第136回生物科学フロンティアセミナー 世話人：藤井郁雄、中瀬生彦 「A peptide-based approach to fight SARS-COV-2: from vaccines to antivirals」 Professor Dr. Anna Maria Papini (Department of Chemistry, University of Florence) （2023年11月13日、大阪公立大学 中百舌鳥キャンパス）
